Patients with sodium channelopathy-related small fibre neuropathy usually have inherited the mutation from one of their parents. The chance of transmitting the mutation to a child is 50%; this is called autosomal dominant inheritance. There is no effect of gender.

The disorder does not skip generations. If a person does not have the mutation, he or she cannot transmit the mutation to a next generation.

Occasionally the genetic change is a de novo (new) mutation. In that case the disease will not occur in parents or siblings. Not every person with a mutation will develop the same complaints. Some patients don’t have any complaints at all.