Chronic pain, such as in small fibre neuropathy, often is accompanied by depression and /or anxiety (affective symptoms). Whether there is a direct causal (biological) connection, is yet unknown. However, in general, pain can lead to affective symptoms, and affective symptoms on the other hand may influence pain, leading to an increased pain perception in patients with affective symptoms.

Besides the impact of having pain, the pain in small fibre neuropathy often cannot be completely alleviated, and there is uncertainty about the course of symptoms.
Therefore, for some patients a consultation with a psychiatrist is very helpful. The psychiatrist or nurse practitioner will focus on how to handle the pain, the decreased capacity and the consequent impairment in daily functioning.