The diagnosis small fibre neuropathy cannot be made on basis of a single (blood) test. Neurological examination most often does not reveal abnormalities, because muscle strength, tendon reflexes and vibration sense are all normal.

International doctors and scientists agreed that there is a small fibre neuropathy if there are two ore more typical complaints compatible with small fibre neuropathy, in combination with an abnormal density of the nerve fibres in a skin biopsy and/or abnormal temperature threshold testing.

Further research into easy to use and better tests for the diagnosis small fibre neuropathy are being performed.